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Cholinergic Blockers

  • Located postsynaptically:
    • Smooth muscle
    • Cardiac muscle
    • Glands of parasympathetic fibers
    • Effector organs of cholinergic sympathetic fibers
  • Named “muscarinic” because can be stimulated by the alkaloid muscarine


  • Stimulate intestine and bladder
    • Increased gastric secretions
    • Increased gastrointestinal motility
    • Increased urinary frequency
  • Stimulate pupil
    • Constriction (miosis)
    • Reduced intraocular pressure
  • Increased salivation and sweating

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