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Antianginal Agents

  • Therapeutic Objectives
  • Minimize the frequency of attacks and decrease the duration and intensity of anginal pain
  • Improve the patient’s functional capacity with as few side effects as possible
  • Prevent or delay the worst possible outcome, MI


  • Nitroglycerin
  • Prototypical nitrate
  • Large first-pass effect with PO forms
  • Used for symptomatic treatment of ischemic heart conditions (angina)
  • IV form used for BP control in perioperative hypertension, treatment of CHF, ischemic pain,
    and pulmonary edema associated with acute MI

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