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Beta Adrenergic Blockers

  • Lipid soluble agents (vs. water soluble) tend to:
    • Be better absorbed
    • Have more variable bioavailability
    • Be metabolized in liver
    • Enter the CNS
    • Be more widely distributed
    • Have shorter elimination half-lives

 

  • Cardiac (mechanical; electrical)
  • Vascular (decreased perfusion)
  • Pulmonary (bronchocostriction)
  • Metabolic (diabetes mellitus)
  • Central Nervous System (depression, nightmares, etc.)
  • Withdrawal Syndrome

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