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BIOMED


Tissue damage releases bradykinin, serotonin, histamin, lactate, ATP, ADP, potassium (among others)
Glutamate (excitatory) transmittor in dorsal horn synapse
GABA (inhibitory) transmittor interneuron
Nociceptive neurons in dorsal root ganglion
Relays via tractus spinothalamicus, spinomesencephalicus and spinoreticularis
Reaches thalamus and pons
Connects to cortex
Inhibitory neurons
Inhibitory mechanoreceptors

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