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CNS Stimulants3

  • Imbalance between inhibitory and excitatory
  • processes as in the brain.  This hyper-excitability
  • of neurons results from:
  •  potentiation or enhancement of excitatory neurotransmission(e.g. amphetamine)
  •  depression or antagonism of inhibitory transmission (e.g. Strychnine)
  • presynaptic control of neurotransmitter release (e.g. picrotoxin)


  • diverse chemical class of agents
  • majority can be absorbed orally
  • have a short duration of action – primary expression of pharmacological effect is convulsions (tonic-clonic) uncoordinated
  • pharmacological effect is terminated through hepatic metabolism
  • Possible Common Mechanism of Action -ability to alter movement of chloride ions across neuronal membranes
  • Therapeutic Uses Group as a whole has limited therapeutic use.

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