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dr ajit mishra tnf final

  •   Role in Lichen Planus
  •   Keratinocyte from oral Lichen Planus lesion produce IFN- alpha, IL-6 and TNF- alpha in response to IL-beta. Theses keratinocyte thus have the potential to produce large amount of cytokines capable of activating infiltrating T cells

 

It might be possible that some side effects of human recombinant TNF-alpha administered are connected with the decreasing cortisol level because TNf induces  intergrin expression and adherence properties.

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