Home / Orthodontics / Genetics & Malocclusion II

Genetics & Malocclusion II

  • INTRODUCTION
  • ROLE OF NEURAL CREST CELLS
  • VERTEBRATE HOX GENES
  • VERTEBRATE HOX CODE
  • PATTERNING THE BRANCHIAL REGION OF THE HEAD
  • PATTERNING OF FACE AND JAWS
  • PATTERNING THE MIDLINE
  • PATTERNING OF THE DENTITION
  • GENETIC INFLUENCE ON TOOTH NUMBER, SIZE, MORPHOLOGY, POSITION AND ERUPTION
  • HERITABILITY OF MALOCCLUSION
  • FAMILY AND TWIN STUDIES FOR HERITABILITY OF DENTOFACIAL PHENOTYPES
  • GENETIC FACTORS AND HERITABILITY OF VERTICAL DIMENSION MALOCCLUSION
  • HERIABILITY OF LOCAL OCCLUSAL VARIABLES
  • GENOMICS AND OROFACIAL CLEFTS
  • CRANIOFACIAL SYNDROMES
  • CONCLUSION
  • In the early 1980s biologists began searching for genes containing the Drosophila homeobox in vertebrates, reasoning that the highly conserved nature of the homeobox between homeotic genes might have been preserved during evolution. In a landmark evolutionary survey, using DNA from a variety of species, it was shown that the homeobox is not confined to insects, but is also found in vertebrates.
  • The first vertebrate homeobox was rapidly cloned in the frog, Xenopus levis and this was soon followed by the mouse. The degree of sequence similarity to the Drosophila homeobox was remarkable, confirming that the genetic control of development was more universal than previously imagined. These vertebrate genes are called Hox genes, and as more were cloned it became clear that during the course of evolution considerable duplication a divergence had occurred from the original ancestral cluster.

About indiandentalacademy

Leave a Reply

Your email address will not be published. Required fields are marked *