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Oral Medicine

ANAGESICS IN DENTISTRY

1949: The NSAID Phenylbutazone introduced 1963: Indomethacin introduced 1971: Vane and Piper demonstrated NSAIDs inhibit prostaglandin production 1974: Ibuprofen introduced 1976: Miyamoto et al  purified the COX-1 enzyme 1989: Simmons et al identified the COX-2 enzyme 1999: The COXIBs Celebrex (celecoxib) and Vioxx (rofecoxib) introduced   Non selective COX inhibitors …

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