Genetic paradigm cannot be rejected as such
Both genetic and functional paradigm have to coexist and be applicable for the benefit of the patient.
Functional matrix hypothesis is not synonymous with functional paradigm. It is an extreme but legitimate way of expressing the functional paradigm.
Experimental design and results are influenced by the paradigm maintained by the investigator.
Paradigm provides a coherent conceptual scheme to organize observations and ideas, determining which are relevant, which problems are legitimate and indicating how these problems may be solved.
A single paradigm may be the basis for many theories and certainly for numerous hypothesis, even if they are in conflict with each other.