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S1_GIdrugs_000

  • Peptic ulcer disease/dyspepsia
  • GORD
  • Inflammatory bowel disease
  • Irritable bowel syndrome
  • Diarrhoea
  • Constipation
  • Pancreatitis

 

  • Antiinflammatory
  • Analgesic
  • Antipyretic
  • Chemically heterogeneous
  • Reversible competitive inhibitors of COX activity (Aspirin irreversible)
  • Reduce prostaglandin synthesis (COX-1)
    • ↓ Mucus
    • ↓ bicarbonate
    • ↓ blood flow
    • ↓ proliferation of cells
    • ↑ gastric acid secretion
  • Reduce production of superoxide radicals, induce apoptosis, inhibit expression of adhesion molecules, decrease NO synthase and proinflammatory cytokines, modify lymphocyte activity and alter cellular membrane functions
  • Biliary excretion and reflux of metabolites into stomach

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