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shekar kapoor

  • First reported by Demarquay et al in 1845.
  • Van Der Woude (1954),  found  autosomal dominant mode of inheritance
  • Janku et al. (1980) traced  syndrome through 7 generations.
  • Lip pits, were present in 88% of the affected and were the only manifestation in 64%. Clefts of lip and palate occurred in 21%.
  • Penetrance was 96.7%.
  • Autosomal dominant syndrome
  • most common syndrome associated with cleft lip or cleft palate
  • characterized by a cleft lip or cleft palate, distinctive pits of the lower lips, or both


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