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stain -toludin blue

  • Diagnostic efficacy of Lugol’s iodine and Toluidine blue in oral premalignant and malignant lesions; Kamarthi Nagaraju et al; Indian Journal of Dental Reaserch;2010.
  • Advanced Diagnostic Aids in Oral Cancer; KMK Masthan et al; Asian Pacific J Cancer Prev,2012; 13, 3573-3576.
  • Supravital Staining: It’s Role In Detecting Early Malignancies;Mahesh Chandra Hegde, Panduranga M et al:Indian Journal of Otolaryngology and Head and Neck Surgery Vol. 58, No. 1, January-March 2006.
  • 06-Cell Patholgy – Ch 06; Staining theory.


  • Endocrine cells:
  • Many endocrine cells exhibit masked metachromasia.
  • This characteristic can be unmasked by prior treatment of tissue sections by hot acid hydrolysis by HCl.
  • This releases carboxyl groups from polypeptides which are then free to react with and change the color of basic dyes such as toluidine blue.
  • Endocrine cell granules stain – purple to red.

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