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structure of HIV virus

  • INTRODUCTION
  • CHARACTERISTICS OF HIV VIRUS
  • STRUCTURAL GENES
  • LIFE CYCLE OF HIV VIRUS
  • VIRAL REPLICATION
  • PRIMARY HIV SYNDROME
  • HIV ASSOCIATED OPPORTUNISTIC INFECTIONS
  • INFANTS WITH HIV
  • IMMUNOLOGICAL MANIFESTATIONS
  • LAB DIAGNOSIS OF HIV INFECTION
  • Envelope (Env) gene codes for envelope proteins gp160, gp120 and gp41.
    • These polyproteins will eventually be cleaved by proteases to become HIV envelope glycoproteins gp120 and gp41.
    • gp160 cleaved to form gp120 and gp41.
    • gp120 forms the 72 knobs which protrude from outer envelope.
    • gp41 is a transmembrane glycoprotein antigen that spans the inner and outer membranes and attaches to gp120.
    • gp120 and gp41 both involved with fusion and attachment of HIV to CD4 antigen on host cells.

 

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