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STRUCTURES OF BASEMENT MEMBERANE

“Basement  membranes are thin layers of a specialized extra-cellular matrix that  form  the supporting structure on which epithelial and  endothelial cells grow and that surround muscle  and fat cells and the schwann cells of  peripheral  nerves.”

 

  • The interstitial collagen (type I and type III) act as supportive structures which along with typeIV in the lamina densa  and anchoring fibrils froms a meshwork providing support to cell structure.
    The laminins which are multi adhesive proteins present in lamina lucida attach to integrin i.e. alpha6beta4 which is a single transmemberane adhesion molecule, binding to BP 230 and  BP 180 which play an important role in maintaining linkage between intracellular and extracellular structural elements involved in epidermal adhesion.

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