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Verrucous & Melanoma

  • OSCC
  • Fast growing
  • Usually ulcerated
  • Invasive
  • High metastasis
  • Radical treatment
  • Prognosis poor
  • Verrucous carcinoma
  • Slow growing
  • Exophytic growth
  • Superficial invasive
  • Low metastatic potential
  • Simple local excision
  • Good prognosis
  • Marked epithelial proliferation
  • Downgrowth of epithelium without true invasion
  • Well differentiated epithelium with little mitotic activity
  • Cleft like spaces lined by parakeratin
  • Hallmark is parakeratin plugging
  • Basement membrane often appears intact
  • Incase of inflammation focal intraepithelial abscess formation is seen

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