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viral diseases 1

  • Pathogenesis of HIV infection
  • After binding – internalized in to the host cell – uncoated – viral RNA then reverse transcribed in to linear double stranded DNA in cytoplasm – transported to nucleus – integrated in the host cell – transcribed in to full length RNA – leads to genome of progeny virus or synthesis of viral gene products

 

  • Clinical features
  • Asymptomatic to severe clinical illness and AIDS
  • Symptomatic  HIV infection k/as AIDS related complex, characterized by development of opportunistic infections (CD4count < 500 cells/mm3 )
  • AIDS diagnosed when (CD4count < 200 cells/mm3 )
  • Overwhelming opportunistic infections and death (CD4count < 200 cells/mm3 )

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